For medical or scientific research purposes, many biological samples ,such as skin, liver samples, cells, vaccines, need to be stored for a long time. But how and where should these samples be stored?
Medical reagents, biological agents, enzymes, vaccines and medicines:Medical reagents, vaccines, drugs, etc., are susceptible to deterioration and failure due to external influences, stored at an appropriate temperature, can effectively slow down the degradation or failure of the active ingredient. Reefer vaccines, monoclonal antibodies, insulin, interferons, etc., including most of the COVID-19 vaccines, are stored in 2~8℃ pharmacy refrigerator. The pharmacy refrigerator can maintain good temperature uniformity,for example, Meling 2~8℃ pharmacy refrigerators can control the temperature in the chamber within the set temperature range of ±1℃, to reduce the risk of damage caused by temperature fluctuation.Some vaccines have stricter requirements for storage temperature. For example, Modena vaccine requires -25 ℃, and Pfizer vaccine requires -70 ℃, where the -25℃ biomedical freezer and -86 ultra low temperature freezer are needed.
Bacteria, viruses or other animal and plant specimens, as well as some special cells, skins, organs or other living samples that need to be preserved or studied by hospitals and scientific research institutions:The skin for treating burns and chronic ulcers is not always available,so we usually require skin bank to reserve in advance. Using antifreeze, the skin can be stored at -75℃ for up to six months. Thawing before use, it can be readily available for clinical transplantation.
For cell preservation, cryopreservation solutions or cryprotective agent are often used to help cells resist changes in osmotic pressure and reduce the formation of intracellular ice crystals, thus improving survival.And the freezing rate is also a key factor affecting survival, neither too fast nor too slow, and the optimal cryopreservation rate of different cells is different.When resuscitation, the current common method is rapid recovery, generally use 37℃ water bath. At present, the survival rate of resuscitation cells after deep cryopreservation at -80℃ and -196℃ is about 80%. The storage of cells can be of great help in clinical treatment, such as storing liver cells to help treat liver failure. Store plant seeds in liquid nitrogen at -196℃ after pre-storage at -70℃, and cell metabolism almost stopped, which provided an effective way for long-term utilization of effective genes in plant population.
Blood preservation:After the blood is removed from the body, it is difficult to guarantee that it will not change even in a short time.Therefore, the blood for blood test or emergency blood treatment must be stored in special equipment .The common blood preservation is to store whole blood or red blood cells in a 4±1℃ blood bank refrigerator. Before transfusion,the blood can be transferred to a 22℃ blood refrigerator for reserve.Meling XC-90W blood transport refrigerator can meet both temperature requirements. The temperature can be set to 4℃ for storage, or to 22℃ for use.
Preservation of gene or semen of good breeds in animal husbandry system:After the semen is collected,prolong its survival time in vitro and maintain its fertilization ability,this can make it available at any time for artificial insemination,which is of great significance for improving the utilization rate of good breeds and improving the quality of herds.Sperms can survive for a long time at -79℃ or -196℃ liquid nitrogen,where you can use the ultra low temperature freezers or liquid nitrogen tank.Liquid nitrogen storage can better guarantee the stability of samples, but attention should be paid to sealed storage to prevent cross infection caused by liquid nitrogen penetration.
Some electronic components or precision instruments in chemical industry need low temperature treatment,also need to use this kind of low temperature equipment.The operating temperature of industrial grade components is required to be between -40℃ and +85℃. Therefore, it is necessary to carry out low-temperature test on components before leaving the factory to verify their product performance and ensure that cracking, embrittlement, sticking of movable parts and characteristic changes will not occur at low temperature.In order to create such low temperature conditions,you may need to use -40℃ or -80℃ ultra-low temperature freezer.
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